For over two decades the Issa Lab has studied the function of specific genes that encode epigenetic regulators. Utilizing our proprietary screening tools we are able to determine and validate a compounds’ potential epigenetic activity. We study small molecules in cellular and animal models of disease to identify and validate potential epigenetic targets. We have identified a new molecule that targets the epigenetic activity of CDK9, leading to cancer cell inhibition and sensitivity to chemotherapy and immunotherapy.